ZC3HAV1 Antibodies

AND ZC3HAV1 ELISA kits, ZC3HAV1 Proteins

Many biological assays use antibodies to detect ZC3HAV1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ZC3HAV1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ZC3HAV1 antibodies...

We validate the specificity of these antibodies to ZC3HAV1 by testing them on tissues known to express ZC3HAV1 positively and negatively. Browse below to find the ZC3HAV1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ZC3HAV1 Infographic by Boster Bio

All ZC3HAV1 Products

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Anti-ZC3HAV1 Antibody

Human

ELISA, IF, ICC, WB

$449
Cat # A04199
0.1 mg

ZC3HAV1 (NM_020119) Human Over-expression Lysate

Human

$960
Cat # LS056829
100 µg

ZC3HAV1 Overview

Facts about Zinc finger CCCH-type antiviral protein 1.

ZC3HAV1 3D structure. Source: alphafold

Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1)

Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)- specific ribonuclease PARN to remove the poly(A) tail, and the 3'- 5' exoribonuclease complex exosome to degrade the RNA body in the 3'-end.

Additionally, it recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to commence its own degradation from the 5'-end. Its target viruses belong to families including retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV).

Gene Information

Human
Gene Name:	ZC3HAV1
Uniprot:	Q7Z2W4
Entrez:	56829

Family

Belongs to:

No superfamily

Alternative Names

FLB6421DKFZp686O19171; FLJ13288antiviral 1; ZAPDKFZp686F2052; ZC3HDC2DKFZp686H1869; Zinc finger antiviral protein; Zinc finger CCCH domain-containing protein 2; zinc finger CCCH-type antiviral protein 1; zinc finger CCCH-type, antiviral 1

Molecular Weight

Mass (kDA):
101.431 kDA

Genomic Context


Human

Location:	7q34
Sequence:	7; NC_000007.14 (139043515..139109720, complement)

Subcellular Localizations

[Isoform 1]: Cytoplasm. Nucleus. Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner.; [Isoform 2]: Cytoplasm.

Diseases

Infective Disorder
Sclerosis
Influenza
Urticaria
Infectious Mononucleosis
Multiple Sclerosis
Influenza In Birds
Aids Dementia Complex
Encephalitis

Headache
Hiv Infections
Inflammation

Interacting Proteins

DDX58

Pathways

Developmental Process
Metabolic Process
Response To Stimulus
Biological Regulation
Post-translational Protein Modification
Cognition
Primary Metabolic Process

Chromatin Remodeling

PTMs

Acetylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ZC3HAV1

References

PMID: 18225958 by Kerns J.A., et al. Positive selection and increased antiviral activity associated with the PARP-containing isoform of human zinc-finger antiviral protein.

PMID: 18418085 by Zhu Y., et al. ZAP-mediated mRNA degradation.