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- Table of Contents
Facts about Endoribonuclease ZC3H12A.
Prevents aberrant T-cell-mediated immune response by degradation of multiple mRNAs controlling T- cell activation, like those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL) (By similarity). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs.
Human | |
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Gene Name: | ZC3H12A |
Uniprot: | Q5D1E8 |
Entrez: | 80149 |
Belongs to: |
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ZC3H12 family |
MCPIP1; ZC3H12A; zinc finger CCCH-type containing 12A
Mass (kDA):
65.699 kDA
Human | |
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Location: | 1p34.3 |
Sequence: | 1; NC_000001.11 (37474518..37484377) |
Expressed in heart, placenta, spleen, kidney, liver and lung (PubMed:19909337). Expressed in leukocytes (PubMed:19909337). Expressed in monocyte (PubMed:16574901).
Nucleus. Cytoplasm. Cytoplasm, P-body. Rough endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic granule. Predominantly localized in the cytoplasm. Colocalizes with GW182 on many granule-like structures, probably corresponding to cytoplasmic GW bodies (GWBs), also called processing bodies (P bodies). Colocalizes with calnexin on the surface of the rough endoplasmic reticulum (RER) membrane and with translationally active polysomes (By similarity). Colocalizes with ZC3H12D in cytoplasmic mRNA processing P-body, also known as GW bodies (GWBs) (PubMed:220551
PMID: 16574901 by Zhou L., et al. Monocyte chemoattractant protein-1 induces a novel transcription factor that causes cardiac myocyte apoptosis and ventricular dysfunction.
PMID: 18178554 by Liang J., et al. A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages.