Endoribonuclease ZC3H12A (ZC3H12A)

Endoribonuclease involved in a variety of biological functions like cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation- associated mRNAs, such as IL6 and IL12B, during the first phase of inflammation (PubMed:26320658).

Prevents aberrant T-cell-mediated immune response by degradation of multiple mRNAs controlling T- cell activation, like those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL) (By similarity). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs.