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- Table of Contents
Facts about Zinc finger and BTB domain-containing protein 7A.
Efficiently abrogates E2F1- dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3'.
Mouse | |
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Gene Name: | Zbtb7a |
Uniprot: | O88939 |
Entrez: | 16969 |
Belongs to: |
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No superfamily |
DKFZp547O146; Factor binding IST protein 1; Factor that binds to inducer of short transcripts protein 1; FBI-1; FBI-1POK erythroid myeloid ontogenic factor; FBI1TTF-I-interacting peptide 21; HIV-1 inducer of short transcripts binding protein; Leukemia/lymphoma-related factor; LRF; LRFHIV-1 1st-binding protein 1; lymphoma related factor; MGC99631; Pokemon; TIP21; ZBTB7A; ZBTB7zinc finger and BTB domain containing 7; zinc finger and BTB domain containing 7A; zinc finger and BTB domain containing 7A, HIV-1 inducer of short transcriptsbinding protein; zinc finger and BTB domain-containing protein
Mass (kDA):
60.281 kDA
Mouse | |
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Location: | 10|10 C1 |
Sequence: | 10; |
Widely expressed. In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level). In the spleen, mainly expressed in the white pulp germinal centers (at protein level). Up-regulated in thymic lymphomas.
PMID: 9927193 by Davies J.M., et al. Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene.
PMID: 14701838 by Laudes M., et al. Role of the POZ zinc finger transcription factor FBI-1 in human and murine adipogenesis.