LRP6 Antibodies

AND LRP6 ELISA kits, LRP6 Proteins

Many biological assays use antibodies to detect LRP6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LRP6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LRP6 antibodies...

We validate the specificity of these antibodies to LRP6 by testing them on tissues known to express LRP6 positively and negatively. Browse below to find the LRP6 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LRP6 Infographic by Boster Bio

All LRP6 Products

Product

Figures

Specificity

Applications

Price

Anti-LRP6 Antibody

Human, Mouse

ELISA, WB

$380
Cat # A00970
100ul

Anti-LRP6 Rabbit Monoclonal Antibody

Human, Mouse, Rat

Flow Cytometry, IF, ICC, WB

$370
Cat # M00970
100 μl/vial

LRP6 (NM_002336) Human Over-expression Lysate

Human

$960
Cat # LS004040
100 µg

Anti-Phospho-LRP6 (S1490) Rabbit Monoclonal Antibody

Human

$370
Cat # M00970S1490
100 µl/vial

LRP6 Overview

Facts about Low-density lipoprotein receptor-related protein 6.

LRP6 3D structure. Source: alphafold

Low-density lipoprotein receptor-related protein 6 (LRP6)

Component of the Wnt-Fzd-LRP5-LRP6 complex that activates beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation.

The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and degradation of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).

Gene Information

Human
Gene Name:	LRP6
Uniprot:	O75581
Entrez:	4040

Family

Belongs to:

LDLR family

Alternative Names

ADCAD2; FLJ90062; FLJ90421; low density lipoprotein receptor-related protein 6; low-density lipoprotein receptor-related protein 6; LRP6; LRP-6

Molecular Weight

Mass (kDA):
180.429 kDA

Genomic Context


Human

Location:	12p13.2
Sequence:	12; NC_000012.12 (12116025..12267044, complement)

Tissue Specificity

Widely coexpressed with LRP5 during embryogenesis and in adult tissues.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Membrane raft. On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD (By similarity).