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- Table of Contents
Facts about Zinc finger and BTB domain-containing protein 4.
Binds with a greater affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and may bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688).
Human | |
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Gene Name: | ZBTB4 |
Uniprot: | Q9P1Z0 |
Entrez: | 57659 |
Belongs to: |
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No superfamily |
KAISO-L1; zinc finger and BTB domain containing 4
Mass (kDA):
105.114 kDA
Human | |
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Location: | 17p13.1 |
Sequence: | 17; NC_000017.11 (7459366..7484249, complement) |
Nucleus. Chromosome. Localizes to chromocenters.
PMID: 16354688 by Filion G.J., et al. A family of human zinc finger proteins that bind methylated DNA and repress transcription.
PMID: 19448668 by Yamada D., et al. The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4.