Zinc finger and BTB domain-containing protein 4 (ZBTB4)

Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent method.

Binds with a greater affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and may bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688).