DNA repair protein XRCC2 (XRCC2)

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which functions from the BRCA1-BRCA2- dependent HR pathway.

Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the junction of the four duplex arms of the Holliday junction and to junction of replication forks.