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14-3-3 protein beta/alpha Antibodies
AND YWHAB ELISA kits, 14-3-3 protein beta/alpha Proteins
Many biological assays use antibodies to detect 14-3-3 protein beta/alpha, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with 14-3-3 protein beta/alpha in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop 14-3-3 protein beta/alpha antibodies...
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YWHAB Infographic by Boster Bio
All YWHAB Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$481
Cat # P02431
100 µl
Cat # P02431
100 µl
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # M02431-1
100 μl
Cat # M02431-1
100 μl
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M02431-3
100 μl
Cat # M02431-3
100 μl
YWHAB Overview
Facts about 14-3-3 protein beta/alpha.
14-3-3 protein beta/alpha (YWHAB)
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a lot of partners, usually by recognition of a phosphoserine or phosphothreonine motif.
Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis.
Gene Information
| Human | |
|---|---|
| Gene Name: | YWHAB |
| Uniprot: | P31946 |
| Entrez: | 7529 |
Family
| Belongs to: |
|---|
| 14-3-3 family |
Alternative Names
14-3-3 alpha; 14-3-3 beta; 14-3-3 protein beta/alpha; brain protein 14-3-3, beta isoform; GW128; HS1; KCIP-1; Protein 1054; Protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alphapolypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, betapolypeptide; YWHAA
Molecular Weight
Mass (kDA):
28.082 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q13.12 |
| Sequence: | 20; NC_000020.11 (44885705..44908532) |
Subcellular Localizations
Cytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.; Vacuole membrane. (Microbial infection) Upon infection with Chlamydia trachomatis, this protein is associated with the pathogen-containing vacuole membrane where it colocalizes with IncG.
Diseases
- Malignant Neoplasms
- Neoplasms
- Creutzfeldt-jakob Disease
- Tissue Adhesions
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Neoplasm Metastasis
- Nervousness
- Glioblastoma
- Asthma
- Colorectal Cancer
- Nerve Degeneration
Interacting Proteins
- BRAF
- CBL
- CBX4
- CDC25A
- CDC25B
- CDC25C
- CDK14
- DACT1
- GAB2
- GEM
Pathways
- Localization
- Cell Cycle
- Cell Adhesion
- Cell Death
- Cell Growth
- Pathogenesis
- Transport
- Cell Migration
- Immune Response
- Phagocytosis
- Regulation Of Cell Adhesion
- Induction Of Apoptosis
- Response To Lipopolysaccharide
PTMs
- Phosphorylation
- Dephosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/YWHAB
bosterbio.com/bosterbio-gene-info-cards/YWHAB
References
PMID: 8515476 by Leffers H., et al. Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway.
PMID: 23572552 by Greninger A.L., et al. ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding.