Lymphotactin Antibodies

Lymphotactin (XCL1)

Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and leads to regulatoy T cell growth, playing a role in self-tolerance establishment.

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Gene Information

Human
Gene Name:	XCL1
Uniprot:	P47992
Entrez:	6375

Family

Belongs to:
intercrine gamma family

Alternative Names

ATAC; ATACSmall-inducible cytokine C1; C motif chemokine 1; chemokine (C motif) ligand 1; Cytokine SCM-1; LPTNSCM-1-alpha; LTNXC chemokine ligand 1; Lymphotactin; lymphotaxin; SCM-1 alpha; SCM-1; SCM1A; SCM-1a; SCYC1SCM1; single cysteine motif 1a; small inducible cytokine subfamily C, member 1 (lymphotactin); XCL1

Molecular Weight

Mass (kDA):
12.517 kDA

Genomic Context

Human
Location:	1q24.2
Sequence:	1; NC_000001.11 (168574128..168582069)

Tissue Specificity

Highest level in spleen, lower in peripheral leukocytes and very low levels in lung, colon and small intestine.

Subcellular Localizations

Secreted.

Diseases

• Neoplasms
• Inflammation
• Malignant Neoplasms
• Carcinoma
• Cholangiocarcinoma
• Tissue Adhesions
• Neoplasm Metastasis
• Arthritis
• Tuberculosis
• Melanoma
• Delayed Hypersensitivity
• Granuloma

• Infective Disorder
• Melanoma, Experimental
• Rheumatoid Arthritis
• Autoimmune Diseases
• Autoimmune Reaction
• Malignant Paraganglionic Neoplasm

Interacting Proteins

• CCL13
• CCL26
• CCL5
• CXCL12
• PF4

• PF4V1

Pathways

• Chemotaxis
• Immune Response
• Secretion
• Cell Migration
• Pathogenesis
• Lymphocyte Migration
• Hypersensitivity
• Monocyte Chemotaxis
• Phagocytosis
• Cytokine Production
• Cell Adhesion
• Cell Proliferation
• Chemokinesis

• Leukocyte Migration
• Lymphocyte Chemotaxis
• T Cell Proliferation
• Cell Death
• Cell Activation
• Cell Division
• Granuloma Formation

PTMs

• Glycosylation
• Cleavage

• Reduction
• Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/XCL1

Best Uses of the XCL1 Marker

As a scientist, you might have trouble determining which applications or special samples are best suited for the Boster Bio. That's why we've compiled a list of troubleshooting guides, updates, and optimization tips for Boster Bio. These tips apply to all scientists, regardless of whether they're in the laboratory or not. Read on to learn about the best uses of the XCL1 marker.

Boster Bio optimization tips

If you are looking to optimize the IHC of the XCL1 marker, Boster Bio offers a complete line of secondary antibodies, isotype controls, and detection systems for the XCL1 marker. Here are some commonly asked questions and answers from Boster Bio customers. What are negative control conditions and how do you prepare them? Read on to find out. Then, be sure to download the Boster Bio protocol to optimize your IHC experiments for the XCL1 marker.

Boster Bio troubleshooting guides

If you are new to flow cytometry, Boster Bio's troubleshooting guides can be useful resources. These guides are comprehensive, step-by-step overviews of flow cytometry protocols. They serve as a primer or quick reference guide to common problems and how to solve them. For example, in the IHC protocol, BosterBio covers antigen retrieval, fixation, and embedding. Moreover, the guide also covers the optimal sample preparation technique. It also includes protocols for different types of preserved tissue. Preservation is the key to good staining.

Boster Bio updates

For the development of vaccines for diseases such as SARS and CoV-2, a new marker for XCL1 may help. XCL1 is a receptor protein for a molecule known as XCLO. Using this marker to target these toxins may provide more powerful vaccines on different platforms. However, fusion with XCL1 is a complex process. Here are some of the key benefits of XCL1 fusion.