Xaa-Pro aminopeptidase 2 Antibodies

AND XPNPEP2 ELISA kits, Xaa-Pro aminopeptidase 2 Proteins

Many biological assays use antibodies to detect Xaa-Pro aminopeptidase 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Xaa-Pro aminopeptidase 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Xaa-Pro aminopeptidase 2 antibodies...

We validate the specificity of these antibodies to Xaa-Pro aminopeptidase 2 by testing them on tissues known to express XPNPEP2 positively and negatively. Browse below to find the XPNPEP2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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XPNPEP2 Infographic by Boster Bio

All XPNPEP2 Products

Product

Figures

Specificity

Applications

Price

Anti-Xaa-Pro aminopeptidase 2 XPNPEP2 Antibody

Human, Mouse, Rat

$405
Cat # A09337
100ul

XPNPEP2 (NM_003399) Human Over-expression Lysate

Human

$960
Cat # LS007512
100 µg

XPNPEP2 Overview

Facts about Xaa-Pro aminopeptidase 2.

XPNPEP2 3D structure. Source: alphafold

Xaa-Pro aminopeptidase 2 (XPNPEP2)

Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin.

Gene Information

Human
Gene Name:	XPNPEP2
Uniprot:	O43895
Entrez:	7512

Family

Belongs to:

peptidase M24B family

Alternative Names

Aminoacylproline aminopeptidase; Aminopeptidase P2; APP2; EC 3.4.11.9; mAmP; Membrane-bound aminopeptidase P; Membrane-bound AmP; Membrane-bound APP; xaa-Pro aminopeptidase 2; XPNPEP2; X-Pro aminopeptidase 2; X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound

Molecular Weight

Mass (kDA):
75.625 kDA

Genomic Context


Human

Location:	Xq26.1
Sequence:	X; NC_000023.11 (129738979..129769536)

Tissue Specificity

Expressed in kidney, lung, heart, placenta, liver, small intestine and colon. No expression in brain, skeletal muscle, pancreas, spleen, thymus, prostate, testis and ovary.

Subcellular Localizations

Cell membrane; Lipid-anchor, GPI-anchor.

Diseases

Angioedema
Premature Menopause
Ovarian Failure, Premature
(balanced Rearrangements Or Structural Markers Nec) Or (balanced Translocations)
Chromosomal Translocation
Turner Syndrome
Stomach Neoplasms
Adenocarcinoma
Transfusion Reaction
Coughing
Anemia
Dry Cough

Angioedemas, Hereditary
Hypertensive Disease
Cardiovascular Diseases
Malignant Neoplasm Of Stomach
Malignant Neoplasms
Ace Inhibitor-aggravated Angioedema
Nervousness

Pathways

Flight
Coagulation
Hypersensitivity
Pathogenesis

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/XPNPEP2

References

PMID: 9375790 by Venema R.C., et al. Cloning and tissue distribution of human membrane-bound aminopeptidase P.

PMID: 16175507 by Duan Q.L., et al. A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors.