XIAP-associated factor 1 Antibodies

AND XAF1 ELISA kits, XIAP-associated factor 1 Proteins

Many biological assays use antibodies to detect XIAP-associated factor 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with XIAP-associated factor 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop XIAP-associated factor 1 antibodies...

We validate the specificity of these antibodies to XIAP-associated factor 1 by testing them on tissues known to express XAF1 positively and negatively. Browse below to find the XAF1 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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XAF1 Infographic by Boster Bio

All XAF1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-XIAP-associated factor 1 XAF1 Antibody Picoband®

5 Q&As

Human

IHC, WB

$370
Cat # PA1218
100 μg/vial

Anti-XAF-1 Antibody

Human, Mouse

ELISA, IF, IHC-P, WB

$449
Cat # A03432
0.1 mg

Human XAF1 Recombinant Protein

SDS-PAGE

$250
Cat # PROTQ6GPH4
Starting from 20ug

Anti-XAF1 Antibody Picoband®

Human

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A03432-1
100 μg/vial

XAF1 (NM_017523) Human Over-expression Lysate

Human

$628
Cat # LS054739
100 µg

XAF1 Overview

Facts about XIAP-associated factor 1.

XAF1 3D structure. Source: alphafold

XIAP-associated factor 1 (XAF1)

Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Induces cleavage and inactivation of BIRC4 independent of caspase activation.

Mediates TNF-alpha- induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway.

Gene Information

Human
Gene Name:	XAF1
Uniprot:	Q6GPH4
Entrez:	54739

Family

Belongs to:

No superfamily

Alternative Names

BIRC4-binding protein; BIRC4BPBIRC4 binding protein; HSXIAPAF1; XIAP associated factor 1; XIAPAF1XIAP-associated factor 1

Molecular Weight

Mass (kDA):
34.626 kDA

Genomic Context


Human

Location:	17p13.1
Sequence:	17; NC_000017.11 (6755408..6775647)

Tissue Specificity

Widely expressed. Expression is frequently down-regulated in cancer cell lines. Isoform 5 is widely expressed. Expressed in placenta (at protein level).

Subcellular Localizations

Cytoplasm. Nucleus. Mitochondrion. Found in the cytoplasm and nucleus of placental syncytiotrophoblasts. Translocates to mitochondria upon TNF-alpha treatment.; [Isoform 1]: Nucleus.; [Isoform 5]: Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Malignant Tumor Of Colon
Colonic Neoplasms
Stomach Neoplasms
Cell Transformation, Neoplastic
Malignant Paraganglionic Neoplasm
Malignant Neoplasm Of Stomach
Carcinogenesis
Tumor Progression
Malignant Neoplasm Of Gastrointestinal Tract

Liver Carcinoma
Liver Neoplasms
Leukemia
Colorectal Cancer
Melanoma
Kidney Neoplasm
Malignant Neoplasm Of Urinary Bladder

Interacting Proteins

RNF166

Pathways

Methylation
Cell Death
Cell Cycle
Cell Proliferation
Cell Growth
Gene Silencing
Dna Methylation
Pathogenesis
Programmed Cell Death
Localization
Cell Cycle Arrest
Sensitization
Demethylation

Rna Interference
Mitotic Catastrophe
Angiogenesis
Cell Cycle Checkpoint
Dna Hypermethylation
Proteolysis
Tube Formation

PTMs

Methylation
Demethylation
Phosphorylation

Cleavage
Reduction
Ubiquitination

Research Areas

Apoptosis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/XAF1

References

PMID: 11175744 by Liston P., et al. Identification of XAF1 as an antagonist of XIAP anti-Caspase activity.

PMID: 17570219 by Chung S.K., et al. Frequent alteration of XAF1 in human colorectal cancers: implication for tumor cell resistance to apoptotic stresses.