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WHAMM Antibodies
AND WHAMM ELISA kits, WHAMM Proteins
Many biological assays use antibodies to detect WHAMM, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WHAMM in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WHAMM antibodies...
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WHAMM Overview
Facts about WASP homolog-associated protein with actin, membranes and microtubules.
WASP homolog-associated protein with actin, membranes and microtubules (WHAMM)
Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and together tubular membranes. Its activity in membrane tubulation demands F-actin and interaction with microtubules.
Proposed to use coordinated actin-nucleating and microtubule- binding activities of different WHAMM molecules to induce membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology.
Gene Information
| Human | |
|---|---|
| Gene Name: | WHAMM |
| Uniprot: | Q8TF30 |
| Entrez: | 123720 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
WASP homolog-associated protein with actin, membranes and microtubules; WHDC1
Molecular Weight
Mass (kDA):
90.924 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q25.2 |
| Sequence: | 15; NC_000015.10 (82809628..82836108) |
Tissue Specificity
Expressed in brain, lung, heart, colon and kidney (at protein level).
Subcellular Localizations
Cytoplasm. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasmic vesicle membrane. Golgi apparatus, cis-Golgi network. Localized to a perinuclear compartment near the microtubule-organizing center (MTOC). Also detected on tubulo-vesicular structures in the cell periphery that frequently localized along microtubules.
Diseases
- Tissue Adhesions
- Wiskott-aldrich Syndrome
Pathways
- Transport
- Actin Nucleation
- Membrane Tubulation
- Cell Migration
- Endocytosis
- Localization
- Clathrin-mediated Endocytosis
- Cell Adhesion
- Secretory Pathway
- Intracellular Transport
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WHAMM
bosterbio.com/bosterbio-gene-info-cards/WHAMM
References
PMID: 18614018 by Campellone K.G., et al. WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport.
PMID: 23087206 by Gad A.K., et al. RhoD regulates cytoskeletal dynamics via the actin nucleation- promoting factor WASp homologue associated with actin Golgi membranes and microtubules.