Wdr34 Antibodies

AND Wdr34 ELISA kits, Wdr34 Proteins

Many biological assays use antibodies to detect Wdr34, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Wdr34 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Wdr34 antibodies...

We validate the specificity of these antibodies to Wdr34 by testing them on tissues known to express Wdr34 positively and negatively. Browse below to find the Wdr34 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Wdr34 Infographic by Boster Bio

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DYNC2I2 (NM_052844) Human Recombinant Protein

$1062
Cat # PROTQ96EX3
20 µg

Wdr34 Overview

Facts about WD repeat-containing protein 34.

WD repeat-containing protein 34 (Wdr34)

Critical for ciliary functions, essential to normal development and survival, most probably as a previously unrecognized component of the mammalian dynein-motor-based intraflagellar transport (IFT) machinery. Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways.

Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation in'Thr-184' and'Thr-187' upon Il-1 beta stimulation (By similarity).

Gene Information

Mouse
Gene Name:	Wdr34
Uniprot:	Q5U4F6
Entrez:	71820

Family

Belongs to:

No superfamily

Alternative Names

bA216B9.3; MGC20486; WD repeat domain 34; WD repeat-containing protein 34

Molecular Weight

Mass (kDA):
57.971 kDA

Genomic Context


Mouse

Location:	2\|2 B
Sequence:	2;

Tissue Specificity

Expressed in brain, thymus, heart, lung, liver, spleen, kidney, testis and intestine.

Diseases

Innate Immune Response

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Wdr34

References

PMID: 19521662 by Gao D., et al. WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4- induced NF-kappaB activation pathway.

PMID: 24183451 by Schmidts M., et al. Mutations in the gene encoding IFT dynein complex component WDR34 cause Jeune asphyxiating thoracic dystrophy.