WDR26 Antibodies

AND WDR26 ELISA kits, WDR26 Proteins

Many biological assays use antibodies to detect WDR26, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WDR26 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WDR26 antibodies...

We validate the specificity of these antibodies to WDR26 by testing them on tissues known to express WDR26 positively and negatively. Browse below to find the WDR26 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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WDR26 Infographic by Boster Bio

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WDR26 (NM_001115113) Human Recombinant Protein

$1062
Cat # PROTQ9H7D7
20 µg

WDR26 Overview

Facts about WD repeat-containing protein 26.

WDR26 3D structure. Source: alphafold

WD repeat-containing protein 26 (WDR26)

Acts as a negative regulator in MAPK signaling pathway (PubMed:15378603). Functions as a scaffolding protein to promote G beta:gamma- mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes (PubMed:22065575, PubMed:23625927).

Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a negative regulator of the canonical Wnt signaling pathway by preventing ubiquitination of beta-catenin CTNNB1 from the beta- catenin destruction complex, thus negatively regulating CTNNB1 degradation (PubMed:27098453).

Gene Information

Human
Gene Name:	WDR26
Uniprot:	Q9H7D7
Entrez:	80232

Family

Belongs to:

No superfamily

Alternative Names

MIP2; myocardial ischemic preconditioning up-regulated protein 2; WD repeat domain 26; WD repeat-containing protein 26

Molecular Weight

Mass (kDA):
72.124 kDA

Genomic Context


Human

Location:	1q42.11-q42.12
Sequence:	1; NC_000001.11 (224385143..224434797, complement)

Tissue Specificity

Broadly expressed, with highest levels in heart and skeletal muscle.

Subcellular Localizations

Cytoplasm. Nucleus. Mitochondrion.

Diseases

Neuroblastoma
Severe Combined Immunodeficiency
Hyperplasia

Interacting Proteins

AXIN1

Pathways

Cell Cycle
Cell Growth
Intracellular Signal Transduction
Response To Oxidative Stress
Chemotaxis
Cell Migration
Cell Proliferation
T Cell Migration
Cell Death

Rna Splicing
Leukocyte Migration
Autophagy

PTMs

Phosphorothioation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WDR26

References

PMID: 15378603 by Zhu Y., et al. WDR26: a novel Gbeta-like protein, suppresses MAPK signaling pathway.

PMID: 17041588 by Higa L.A., et al. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.