WDR19 Antibodies

AND WDR19 ELISA kits, WDR19 Proteins

Many biological assays use antibodies to detect WDR19, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WDR19 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WDR19 antibodies...

We validate the specificity of these antibodies to WDR19 by testing them on tissues known to express WDR19 positively and negatively. Browse below to find the WDR19 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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WDR19 Infographic by Boster Bio

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WDR19 Overview

Facts about WD repeat-containing protein 19.

WDR19 3D structure. Source: alphafold

WD repeat-containing protein 19 (WDR19)

Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport (PubMed:20889716). Involved in cilia function and/or assembly (By similarity).

Associates with the BBSome complex to mediate ciliary transport (By similarity). .

Gene Information

Human
Gene Name:	WDR19
Uniprot:	Q8NEZ3
Entrez:	57728

Family

Belongs to:

No superfamily

Alternative Names

DYF-2; FLJ23127; IFT144; intraflagellar transport 144 homolog; KIAA1638Pwdmp; ORF26; Oseg6; PWDMP; WD repeat domain 19; WD repeat membrane protein PWDMP; WD repeat-containing protein 19

Molecular Weight

Mass (kDA):
151.581 kDA

Genomic Context


Human

Location:	4p14
Sequence:	4; NC_000004.12 (39182473..39285810)

Tissue Specificity

Some isoforms are tissue-specific. Highly expressed in the prostate. Lower expression in the cerebellum, pituitary gland, fetal lung, and pancreas. In normal prostate, expressed in both basal and luminal epithelial cells. No expression detected in fibromuscular stromal cells, endothelial cells, or infiltrating lymphocytes. Uniformed expression in prostate adenocarcinoma cells.

Subcellular Localizations

Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium, photoreceptor outer segment. Localizes to photoreceptor connecting cilia, to the base of motile cilia in brain ependymal cells and to the base of and along primary cilia in kidney cells.

Diseases

Craniofacial Abnormalities
Malignant Neoplasm Of Prostate
Jeune Thoracic Dystrophy
Polydactyly
Bardet-biedl Syndrome
Dysostoses
Benign Prostatic Hypertrophy
Carcinoma
Dysplasia
Malignant Neoplasms
Curry-hall Syndrome
Colorectal Cancer

Adenocarcinoma
Neoplasm Recurrence, Local
Prostatic Hyperplasia
Kidney Failure, Chronic
Short Rib-polydactyly Syndrome
Cleft Palate

Pathways

Transport
Intraflagellar Transport
Mrna Modification
Pathogenesis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WDR19

References

PMID: 12906858 by Lin B., et al. Isolation and characterization of human and mouse WDR19,a novel WD- repeat protein exhibiting androgen-regulated expression in prostate epithelium.

PMID: 20889716 by Mukhopadhyay S., et al. TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.