WDR11 Antibodies

AND WDR11 ELISA kits, WDR11 Proteins

Many biological assays use antibodies to detect WDR11, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WDR11 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WDR11 antibodies...

We validate the specificity of these antibodies to WDR11 by testing them on tissues known to express WDR11 positively and negatively. Browse below to find the WDR11 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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WDR11 Infographic by Boster Bio

All WDR11 Products

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Product

Figures

Specificity

Applications

Price

Anti-WDR11 Antibody

Human

$405
Cat # A06920
100ul

WDR11 (NM_018117) Human Over-expression Lysate

Human

$628
Cat # LS055717
100 µg

WDR11 Overview

Facts about WD repeat-containing protein 11.

WDR11 3D structure. Source: alphafold

WD repeat-containing protein 11 (WDR11)

Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis (PubMed:29263200). Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production (PubMed:29263200).

WDR11 complex facilitates the tethering of Adaptor protein-1 complicated (AP-1)-derived vesicles. WDR11 complicated acts together with TBC1D23 to facilitate the golgin- mediated capture of vesicles generated using AP-1 (PubMed:29426865).

Gene Information

Human
Gene Name:	WDR11
Uniprot:	Q9BZH6
Entrez:	55717

Family

Belongs to:

No superfamily

Alternative Names

Bromodomain and WD repeat-containing protein 2; BRWD2DKFZp434L1715; DR11; FLJ10506; FLJ42531; KIAA1351bromodomain and WD repeat domain containing 2; WD repeat domain 11; WD repeat domain 15; WD repeat-containing protein 11; WD repeat-containing protein 15; WDR15

Molecular Weight

Mass (kDA):
136.685 kDA

Genomic Context


Human

Location:	10q26.12
Sequence:	10; NC_000010.11 (120851313..120909525)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasmic vesicle. Golgi apparatus, trans-Golgi network. Shuttles from the cilium to the nucleus in response to Hh signaling (PubMed:29263200). Might be shuttling between the nucleus and the cytoplasm (PubMed:20887964).

Diseases

Hypogonadotropic Hypogonadism
Kallmann Syndrome
Hypogonadism
Neoplasms
Anosmia
Glioma
Malignant Neoplasms
Idiopathic Hypogonadotropic Hypogonadism
Pyotraumatic Dermatitis
Malignant Neoplasm Of Stomach
Chromosomal Translocation
Stomach Neoplasms

Charge Syndrome
Congenital Ocular Coloboma (disorder)
Atresia
Malignant Neoplasm Of Breast
Olfaction Disorders
Carcinogenesis

Pathways

Neuron Migration
Localization
Secretion
Chromatin Remodeling

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WDR11

References

PMID: 11536051 by Chernova O.B., et al. A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells.

PMID: 20887964 by Kim H.G., et al. WDR11, a WD protein that interacts with transcription factor EMX1, is mutated in idiopathic hypogonadotropic hypogonadism and Kallmann syndrome.