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- Table of Contents
Facts about Tryptophan--tRNA ligase, cytoplasmic.
T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression.
Human | |
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Gene Name: | WARS1 |
Uniprot: | P23381 |
Entrez: | 7453 |
Belongs to: |
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class-I aminoacyl-tRNA synthetase family |
Tryptophan--tRNA ligase, cytoplasmic
Mass (kDA):
53.165 kDA
Human | |
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Location: | 14q32.2 |
Sequence: | 14; NC_000014.9 (100333789..100376327, complement) |
Cytoplasm.
PMID: 1761529 by Rubin B.Y., et al. Interferon induces tryptophanyl-tRNA synthetase expression in human fibroblasts.
PMID: 1763065 by Fleckner J., et al. Human interferon gamma potently induces the synthesis of a 55-kDa protein (gamma 2) highly homologous to rabbit peptide chain release factor and bovine tryptophanyl-tRNA synthetase.