WIPF1 Antibodies

AND WIPF1 ELISA kits, WIPF1 Proteins

Many biological assays use antibodies to detect WIPF1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WIPF1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WIPF1 antibodies...

We validate the specificity of these antibodies to WIPF1 by testing them on tissues known to express WIPF1 positively and negatively. Browse below to find the WIPF1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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WIPF1 Infographic by Boster Bio

All WIPF1 Products

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Product

Figures

Specificity

Applications

Price

Anti-WIP WIPF1 Antibody

Human, Mouse, Rat

ELISA, IHC, WB

$380
Cat # A04501
100ul

WIPF1 (NM_001077269) Human Recombinant Protein

$1249
Cat # PROTO43516
20 µg

Anti-WIPF1 Antibody Picoband®

Human, Mouse, Rat

Flow Cytometry, WB

$370
Cat # A04501-2
100 μg/vial

WIPF1 (NM_003387) Human Over-expression Lysate

Human

$960
Cat # LS007456
100 µg

WIPF1 Overview

Facts about WAS/WASL-interacting protein family member 1.

WIPF1 3D structure. Source: alphafold

WAS/WASL-interacting protein family member 1 (WIPF1)

Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL.

May participate in regulating the subcellular localization of WASL, leading to the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of mobile ruffles (By similarity).

Gene Information

Human
Gene Name:	WIPF1
Uniprot:	O43516
Entrez:	7456

Family

Belongs to:

verprolin family

Alternative Names

WAS/WASL interacting protein family, member 1; WAS/WASL-interacting protein family member 1; WASP-interacting protein; WASPIP; WIPMGC111041; WiskProtein PRPL-2; WiskPRPL-2

Molecular Weight

Mass (kDA):
51.258 kDA

Genomic Context


Human

Location:	2q31.1
Sequence:	2; NC_000002.12 (174559574..174682913, complement)

Tissue Specificity

Highly expressed in peripheral blood mononuclear cells, spleen, placenta, small intestine, colon and thymus. Lower expression in ovary, heart, brain, lung, liver, skeletal muscle, kidney, pancreas, prostate and testis.

Subcellular Localizations

Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Cell projection, ruffle. Vesicle surfaces and along actin tails. Colocalizes with actin stress fibers. When coexpressed with WASL, no longer associated with actin filaments but accumulated in perinuclear and cortical areas like WASL (By similarity).

Diseases

Wiskott-aldrich Syndrome
Immunologic Deficiency Syndromes
Neoplasms
Infective Disorder
Eczema
Malignant Neoplasms
Vaccinia
Tissue Adhesions
Protrusion
Shigella Infections
Malignant Neoplasm Of Breast
Mammary Neoplasms

Escherichia Coli Infections
Neurodegenerative Disorders
Low Set Ears
Glioma
Yersinia Pseudotuberculosis Infections
X-linked Combined Immunodeficiency Diseases

Interacting Proteins

ABI2
ALAS1
Cttn
FASTK
GRB2

HCK
HCLS1
HOMER3
NCK1
SEC24C

WAS
WASL
WWP2

Pathways

Cell Activation
Localization
T Cell Activation
Chemotaxis
Phagocytosis
Endocytosis
Cytokinesis
Cell Motility
T Cell Proliferation
Cell Proliferation
Pathogenesis
Secretion
Cell Adhesion

Transport
Cell Migration
Mast Cell Activation
Spermatogenesis
Regulation Of T Cell Activation
Receptor-mediated Endocytosis
Actin Cytoskeleton Reorganization

PTMs

Phosphorylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WIPF1

References

PMID: 9405671 by Ramesh N., et al. WIP, a protein associated with Wiskott-Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells.

PMID: 10202051 by Stewart D.M., et al. Mutations that cause the Wiskott-Aldrich syndrome impair the interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein.