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- Table of Contents
Facts about Syndetin.
Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes into the trans-Golgi network (TGN).
Human | |
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Gene Name: | VPS50 |
Uniprot: | Q96JG6 |
Entrez: | 55610 |
Belongs to: |
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syndetin family |
CCDC132; coiled-coil domain containing 132; coiled-coil domain-containing protein 132; EARP/GARPII Complex Subunit VPS50; KIAA1861; Syndetin; VPS50, EARP/GARPII Complex Subunit; VPS54L
Mass (kDA):
111.174 kDA
Human | |
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Location: | 7q21.2-q21.3 |
Sequence: | 7; NC_000007.14 (93232340..93361123) |
Ubiquitous, with higher expression in brain and skeletal muscle.
Recycling endosome.
PMID: 21472204 by Matsumoto Y., et al. CCDC132 is highly expressed in atopic dermatitis T cells.
PMID: 25799061 by Schindler C., et al. EARP is a multisubunit tethering complex involved in endocytic recycling.