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- Table of Contents
Facts about Vacuolar protein sorting-associated protein 33B.
Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753).
Human | |
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Gene Name: | VPS33B |
Uniprot: | Q9H267 |
Entrez: | 26276 |
Belongs to: |
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STXBP/unc-18/SEC1 family |
FLJ14848; hVPS33B; vacuolar protein sorting 33 homolog B (yeast); vacuolar protein sorting 33B (yeast homolog); vacuolar protein sorting 33B; vacuolar protein sorting-associated protein 33B
Mass (kDA):
70.585 kDA
Human | |
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Location: | 15q26.1 |
Sequence: | 15; NC_000015.10 (90998416..91022839, complement) |
Ubiquitous; highly expressed in testis and low expression in the lung.
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Recycling endosome. Colocalizes in clusters with VIPAS39 at cytoplasmic organelles (PubMed:19109425). Colocalizes with RAB11A and VIPAS39 on recycling endosomes (PubMed:22753090). Colocalizes with AP-3, clathrin, Rab5 and Rab7b (PubMed:21411634). Colocalizes with M.tuberculosis PtpA in the cytosol of tuberculosis-infected macrophages and associates with phagosomes (PubMed:18474358).
PMID: 10894945 by Carim-Todd L., et al. Cloning, mapping and expression analysis of VPS33B, the human orthologue of rat Vps33b.
PMID: 11250079 by Huizing M., et al. Molecular cloning and characterization of human VPS18, VPS11, VPS16, and VPS33.