TINF2 Antibodies

AND TINF2 ELISA kits, TINF2 Proteins

Many biological assays use antibodies to detect TINF2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TINF2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TINF2 antibodies...

We validate the specificity of these antibodies to TINF2 by testing them on tissues known to express TINF2 positively and negatively. Browse below to find the TINF2 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TINF2 Infographic by Boster Bio

All TINF2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-TIN2 TINF2 Antibody

Human, Mouse

$405
Cat # A03070
100ul

Anti-TIN2 TINF2 Antibody

Human

ELISA, IHC, WB

$380
Cat # A03070-1
100ul

Anti-Tin2 (TINF2) Mouse Monoclonal Antibody [Clone ID: OTI2C12]

Human, Mouse, Rat

IHC, WB

$523
Cat # M03070
100 µl

Anti-Tin2 Rabbit Monoclonal Antibody

Human, Mouse, Rat

$370
Cat # M03070-1
100 μl/vial

Tin2 (TINF2) (NM_012461) Human Over-expression Lysate

Human

$628
Cat # LS026277
100 µg

TINF2 Overview

Facts about TERF1-interacting nuclear factor 2.

TINF2 3D structure. Source: alphafold

TERF1-interacting nuclear factor 2 (TINF2)

Component of the shelterin complex (telosome) which is involved in the regulation of telomere length and security. Shelterin partners with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective action, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are processed by DNA repair pathways.

Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.

Gene Information

Human
Gene Name:	TINF2
Uniprot:	Q9BSI4
Entrez:	26277

Family

Belongs to:

No superfamily

Alternative Names

(TRF1)-interacting nuclear factor 2 variant 1; TERF1 (TRF1)-interacting nuclear factor 2; TERF1-interacting nuclear factor 2; TIN2TRF1-interacting nuclear protein 2

Molecular Weight

Mass (kDA):
50.023 kDA

Genomic Context


Human

Location:	14q12
Sequence:	14; NC_000014.9 (24239640..24242674, complement)

Tissue Specificity

Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Subcellular Localizations

Nucleus. Chromosome, telomere. Associated with telomeres.; [Isoform 1]: Nucleus matrix.

Diseases

Dyskeratosis Congenita
Dyskeratosis
Malignant Neoplasms
Pancytopenia
Aplastic Anemia
Anemia
Nephritis
Tubulointerstitial Nephritis
Telomere Shortening
Neoplasms
Leukemia
Nephritis, Interstitial
Inherited Bone Marrow Failure Syndrome

Leukoplakia
Leukoplakia, Oral
Stomach Neoplasms
Carcinoma
Fibrosis
Genomic Instability
Bone Marrow Diseases

Pathways

Telomere Maintenance
Cell Cycle
Localization
Pathogenesis
Dna Repair
Senescence
Aging
Pigmentation
Cell Death
Cellular Senescence
Mitosis
S Phase
Reverse Transcription

Translation
Telomere Binding
Cell Proliferation
Metaphase
Dna Replication
Rna Interference
Cell Adhesion

PTMs

Glycosylation
Biotinylation

Phosphorylation
Methylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TINF2

References

PMID: 10581025 by Kim S.-H., et al. TIN2, a new regulator of telomere length in human cells.

PMID: 12768206 by Loayza D., et al. POT1 as a terminal transducer of TRF1 telomere length control.