Vang-like protein 2 (VANGL2)

Involved in the management of early morphogenesis and patterning of both axial midline structures and the evolution of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea.

Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this procedure. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity).