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- Table of Contents
Facts about Vacuolar protein sorting-associated protein 51 homolog.
VPS51 participates in retrograde transport of acid hydrolase receptors, likely by encouraging tethering and SNARE-dependent combination of endosome-derived carriers into the TGN (PubMed:20685960). Acts as part of the EARP complex that is involved in endocytic recycling.
Human | |
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Gene Name: | VPS51 |
Uniprot: | Q9UID3 |
Entrez: | 738 |
Belongs to: |
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VPS51 family |
ANG2; ANG3; C11orf2; C11orf3; chromosome 11 open reading frame 2; FFR; protein fat-free homolog; vacuolar protein sorting 51 homolog (S. cerevisiae)
Mass (kDA):
86.042 kDA
Human | |
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Location: | 11q13.1 |
Sequence: | 11; NC_000011.10 (65096214..65111862) |
Golgi apparatus, trans-Golgi network. Recycling endosome. Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex (PubMed:25799061).
PMID: 9615229 by Lemmens I.H., et al. Identification and molecular characterization of TM7SF2 in the FAUNA gene cluster on human chromosome 11q13.
PMID: 20685960 by Perez-Victoria F.J., et al. Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex.