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- Table of Contents
Facts about Vacuolar protein sorting-associated protein 18 homolog.
The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to modulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to serve as a Rab5 effector to mediate early endosome fusion probably in particular endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203).
Human | |
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Gene Name: | VPS18 |
Uniprot: | Q9P253 |
Entrez: | 57617 |
Belongs to: |
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VPS18 family |
hVPS18; KIAA1475PEP3; vacuolar protein sorting 18 homolog (S. cerevisiae); vacuolar protein sorting protein 18; vacuolar protein sorting-associated protein 18 homolog
Mass (kDA):
110.186 kDA
Human | |
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Location: | 15q15.1 |
Sequence: | 15; NC_000015.10 (40894410..40903975) |
Ubiquitous. Expression was highest in heart and low in lung.
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle, clathrin-coated vesicle. Cytoplasmic, peripheral membrane protein associated with early endosomes and late endosomes/lysosomes.
PMID: 11250079 by Huizing M., et al. Molecular cloning and characterization of human VPS18, VPS11, VPS16, and VPS33.
PMID: 11382755 by Kim B.Y., et al. Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7.