Protein VAC14 homolog Antibodies

AND VAC14 ELISA kits, Protein VAC14 homolog Proteins

Many biological assays use antibodies to detect Protein VAC14 homolog, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein VAC14 homolog in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein VAC14 homolog antibodies...

We validate the specificity of these antibodies to Protein VAC14 homolog by testing them on tissues known to express VAC14 positively and negatively. Browse below to find the VAC14 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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VAC14 Infographic by Boster Bio

All VAC14 Products

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Specificity

Applications

Price

Anti-VAC14 Antibody (N-Term)

Human

IHC-P, WB

$299
Cat # M04720
50 µl

VAC14 (NM_018052) Human Over-expression Lysate

Human

$960
Cat # LS055697
100 µg

VAC14 Overview

Facts about Protein VAC14 homolog.

VAC14 3D structure. Source: alphafold

Protein VAC14 homolog (VAC14)

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity.

Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.

Gene Information

Human
Gene Name:	VAC14
Uniprot:	Q08AM6
Entrez:	55697

Family

Belongs to:

VAC14 family

Alternative Names

ArPIKfyve; FLJ10305; FLJ36622; MGC149816; protein VAC14 homolog; Tax1 (human T-cell leukemia virus type I) binding protein 1; Tax1 (human T-cell leukemia virus type I) binding protein 2; Tax1-binding protein 2; TAX1BP2FLJ46582; TRXMGC149815; Vac14 homolog (S. cerevisiae)

Molecular Weight

Mass (kDA):
87.973 kDA

Genomic Context


Human

Location:	16q22.1-q22.2
Sequence:	16; NC_000016.10 (70687439..70801158, complement)

Tissue Specificity

Ubiquitously expressed.

Subcellular Localizations

Endosome membrane. Microsome membrane. Mainly associated with membranes of the late endocytic pathway.

Diseases

Nerve Degeneration
Sclerosis
Primary Lateral Sclerosis
Amyotrophic Lateral Sclerosis
Neoplasms
Htlv-i Infections
Gliosis
Charcot-marie-tooth Disease
Adult T-cell Lymphoma/leukemia
Aneuploidy
Malignant Neoplasms
Inflammation

Neurodegenerative Disorders
Leukemia
Instabilities, Chromosomal
Down Syndrome
Lung Diseases
Pancytopenia
Paraparesis

Pathways

Transport
Cell Death
Autophagy
Endosomal Transport
Cell Proliferation
Mitosis
Dna Repair
Hypersensitivity
Endocytosis
Membrane Fusion
Localization
Myelination
Inflammatory Response

Cell Division
Response To Osmotic Stress
Cell Cycle
Synoviocyte Proliferation
Vacuole Inheritance
S Phase
Centrosome Duplication

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/VAC14

References

PMID: 8611628 by Mireskandari A., et al. Isolation of a cDNA clone, TRX encoding a human T-cell lymphotrophic virus type-I Tax1 binding protein.

PMID: 15542851 by Sbrissa D., et al. A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity.