Netrin receptor UNC5B Antibodies

AND Unc5b ELISA kits, Netrin receptor UNC5B Proteins

Many biological assays use antibodies to detect Netrin receptor UNC5B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Netrin receptor UNC5B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Netrin receptor UNC5B antibodies...

We validate the specificity of these antibodies to Netrin receptor UNC5B by testing them on tissues known to express Unc5b positively and negatively. Browse below to find the Unc5b antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Unc5b Infographic by Boster Bio

All Unc5b Products

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Anti-Netrin receptor UNC5B UNC5B Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A03986
100ul

UNC5B (NM_170744) Human Over-expression Lysate

Human

$960
Cat # LS219699
100 µg

Unc5b Overview

Facts about Netrin receptor UNC5B.

Netrin receptor UNC5B (Unc5b)

Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (PubMed:10399920, PubMed:9126742). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis.

Gene Information

Rat
Gene Name:	Unc5b
Uniprot:	O08722
Entrez:	60630

Family

Belongs to:

unc-5 family

Alternative Names

p53RDL1; p53-regulated receptor for death and life protein 1; Protein unc-5 homolog 2; Protein unc-5 homolog B; transmembrane receptor Unc5H2; unc5 (C.elegans homolog) b; unc-5 homolog 2; unc-5 homolog B (C. elegans); UNC5B; UNC5H2; UNC5H2netrin receptor UNC5B

Molecular Weight

Mass (kDA):
103.521 kDA

Genomic Context


Rat

Location:	20q11
Sequence:	20;

Tissue Specificity

Mainly expressed in regions of differentiating neurons. Expressed in the developing sensory ganglia that flank the spinal cord from E12, peaking at E14. Expressed in the roof plate region of the spinal cord from E14.

Diseases

Malignant Neoplasms
Tumor Angiogenesis
Nervousness
Neoplasms
Colorectal Cancer
Pathologic Neovascularization
Inflammation
Tissue Adhesions
Ischemia
Reperfusion Injury
Hypoxia
Carcinoma

Retinal Neovascularization
Cell Invasion
Corneal Diseases
Neoplasm Metastasis
Brain Ischemia
Injury To Kidney
Mammary Neoplasms

Pathways

Angiogenesis
Axon Guidance
Cell Proliferation
Cell Migration
Localization
Cell Adhesion
Tube Formation
Sprouting Angiogenesis
Cell Death
Leukocyte Migration
Chemotaxis
Reverse Transcription
System Development

Wound Healing
Epithelial Cell Proliferation
Dna Methylation
Methylation
Endothelial Cell Migration
Regeneration
Nervous System Development

PTMs

Phosphorylation
Methylation

Demethylation
Cleavage

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Unc5b

References

PMID: 9126742 by Leonardo E.D., et al. Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors.

PMID: 10399920 by Hong K., et al. A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion.