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Uhrf1 Antibodies
AND Uhrf1 ELISA kits, Uhrf1 Proteins
Many biological assays use antibodies to detect Uhrf1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Uhrf1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Uhrf1 antibodies...
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Uhrf1 Infographic by Boster Bio
All Uhrf1 Products
Product
Figures
Specificity
Applications
Price
Anti-UHRF1 Antibody Picoband®
1 Citations 7 Q&As
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9905
100 μg/vial
Cat # PB9905
100 μg/vial
Human, Mouse
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A01156-1
100 µg/vial
Cat # A01156-1
100 µg/vial
Uhrf1 Overview
Facts about E3 ubiquitin-protein ligase UHRF1.
E3 ubiquitin-protein ligase UHRF1 (Uhrf1)
Multidomain protein that serves as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication.
In addition to its role in maintenance of DNA methylation, also plays an integral role in chromatin modification: through its tudor-like regions and PHD- type zinc fingers, specifically recognizes and binds histone H3 trimethylated in'Lys-9' (H3K9me3) and unmethylated in'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Uhrf1 |
| Uniprot: | Q8VDF2 |
| Entrez: | 18140 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
E3 ubiquitin-protein ligase UHRF1; EC 6.3.2; EC 6.3.2.-; FLJ21925; hNP95; huNp95; ICBP90NP95; Inverted CCAAT box-binding protein of 90 kDa; Np95; Nuclear protein 95; Nuclear zinc finger protein Np95; RING finger protein 106; RNF106MGC138707; Transcription factor ICBP90; Ubiquitin-like PHD and RING finger domain-containing protein 1; ubiquitin-like with PHD and ring finger domains 1; ubiquitin-like, containing PHD and RING finger domains, 1; Ubiquitin-like-containing PHD and RING finger domains protein 1
Molecular Weight
Mass (kDA):
88.304 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 17|17 D |
| Sequence: | 17; |
Tissue Specificity
Expressed in thymus, testis, spleen and lung. Within testis, expressed in almost all cells except elongated spermatids.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Carcinogenesis
- Mammary Neoplasms
- Carcinoma
- Leukemia
- Acute Lymphocytic Leukemia
- Neoplasm Metastasis
- Cell Transformation, Neoplastic
- Lymphoma
- Adenocarcinoma
- Malignant Neoplasm Of Lung
Pathways
- Methylation
- Dna Methylation
- Cell Cycle
- Cell Proliferation
- Dna Replication
- Localization
- S Phase
- Cell Cycle Arrest
- Cell Growth
- Maintenance Of Dna Methylation
- Cell Death
- Rna Interference
- Histone Modification
PTMs
- Methylation
- Phosphorylation
- Acetylation
Research Areas
- DNA Repair
- Zinc Finger
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Uhrf1
bosterbio.com/bosterbio-gene-info-cards/Uhrf1
References
PMID: 9880673 by Fujimori A., et al. Cloning and mapping of Np95 gene which encodes a novel nuclear protein associated with cell proliferation.
PMID: 12084726 by Muto M., et al. Targeted disruption of Np95 gene renders murine embryonic stem cells hypersensitive to DNA damaging agents and DNA replication blocks.
1 Publications of Boster Uhrf1 Antibodies & ELISA Kits
- PubMed ID: 10.1111/jcmm.15438, UHRF1 predicts poor prognosis by triggering cell cycle in lung adenocarcinoma
*More publications can be found for each product on its corresponding product page