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USP4 Antibodies
AND USP4 ELISA kits, USP4 Proteins
Many biological assays use antibodies to detect USP4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with USP4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop USP4 antibodies...
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USP4 Overview
Facts about Ubiquitin carboxyl-terminal hydrolase 4.
Ubiquitin carboxyl-terminal hydrolase 4 (USP4)
Deubiquitinating enzyme that eliminates conjugated ubiquitin from target proteins (PubMed:16316627, PubMed:16472766, PubMed:16339847, PubMed:20595234, PubMed:22347420, PubMed:25404403). Deubiquitinates TRIM21 (PubMed:16316627).
Deubiquitinates receptor ADORA2A which increases the quantity of functional receptor in the cell surface (PubMed:16339847). May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3 (PubMed:20595234).
Gene Information
| Human | |
|---|---|
| Gene Name: | USP4 |
| Uniprot: | Q13107 |
| Entrez: | 7375 |
Family
| Belongs to: |
|---|
| peptidase C19 family |
Alternative Names
Deubiquitinating enzyme 4; EC 3.1.2.15; EC 3.4.19.12; MGC149848; MGC149849; ubiquitin carboxyl-terminal esterase 4; ubiquitin carboxyl-terminal hydrolase 4; ubiquitin specific peptidase 4 (proto-oncogene); ubiquitin specific protease 4 (proto-oncogene); ubiquitin thioesterase 4; Ubiquitin thiolesterase 4; ubiquitin-specific processing protease 4; Ubiquitin-specific-processing protease 4; Ubiquitous nuclear protein homolog; UNP; Unph; UNPUnph; USP4
Molecular Weight
Mass (kDA):
108.565 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p21.31 |
| Sequence: | 3; NC_000003.12 (49277144..49340053, complement) |
Tissue Specificity
Overexpressed in small cell tumors and adenocarcinomas of the lung compared to wild-type lung (at protein level). Expressed in the hippocampal neurons.
Subcellular Localizations
Cytoplasm. Nucleus. Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucleus and cytoplasm vary according to the cell type.
Diseases
- Malignant Neoplasms
- Neoplasms
- Retinoblastoma
- Carcinoma
- Adenoma
- Tumors Of Adrenal Cortex
- Malignant Neoplasm Of Adrenal Cortex
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Lung Neoplasms
- Small Cell Carcinoma Of Lung
- Inflammation
- Fanconi Anemia
Interacting Proteins
- ADORA2A
- HUWE1
- RIPK1
- TRIM21
Pathways
- Localization
- Cell Migration
- Proteolysis
- Immune Response
- Rna Interference
- Nuclear Import
- Cell Proliferation
- Cellular Senescence
- Cell Fate Determination
- Endocytosis
- Conjugation
- Nuclear Export
PTMs
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/USP4
bosterbio.com/bosterbio-gene-info-cards/USP4
References
PMID: 7784062 by Gray D.A., et al. Elevated expression of Unph, a proto-oncogene at 3p21.3, in human lung tumors.
PMID: 9464533 by Frederick A., et al. The human UNP locus at 3p21.31 encodes two tissue-selective, cytoplasmic isoforms with deubiquitinating activity that have reduced expression in small cell lung carcinoma cell lines.