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- Table of Contents
Facts about Ubiquitin carboxyl-terminal hydrolase 37.
Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation in Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to stop degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315).
Human | |
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Gene Name: | USP37 |
Uniprot: | Q86T82 |
Entrez: | 57695 |
Belongs to: |
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peptidase C19 family |
Deubiquitinating enzyme 37; EC 3.1.2.15; EC 3.4.19.12; KIAA1594tmp_locus_50; MGC117261; ubiquitin carboxyl-terminal hydrolase 37; ubiquitin specific peptidase 37; ubiquitin specific protease 37; ubiquitin thioesterase 37; Ubiquitin thiolesterase 37; Ubiquitin-specific-processing protease 37; USP37
Mass (kDA):
110.17 kDA
Human | |
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Location: | 2q35 |
Sequence: | 2; NC_000002.12 (218450251..218568393, complement) |
Expressed in brain and prostate.
PMID: 14715245 by Quesada V., et al. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.
PMID: 21596315 by Huang X., et al. Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.