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USP33 Antibodies
AND USP33 ELISA kits, USP33 Proteins
Many biological assays use antibodies to detect USP33, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with USP33 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop USP33 antibodies...
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USP33 Overview
Facts about Ubiquitin carboxyl-terminal hydrolase 33.
Ubiquitin carboxyl-terminal hydrolase 33 (USP33)
Deubiquitinating enzyme involved in various processes like centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period that centrioles duplicate and elongate.
Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to govern the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube at a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1.
Gene Information
| Human | |
|---|---|
| Gene Name: | USP33 |
| Uniprot: | Q8TEY7 |
| Entrez: | 23032 |
Family
| Belongs to: |
|---|
| peptidase C19 family |
Alternative Names
Deubiquitinating enzyme 33; EC 3.1.2.15; EC 3.4.19.12; hVDU1; KIAA1097MGC16868; pVHL-interacting deubiquitinating enzyme 1; ubiquitin carboxyl-terminal hydrolase 33; ubiquitin specific peptidase 33; ubiquitin thioesterase 33; Ubiquitin thiolesterase 33; Ubiquitin-specific-processing protease 33; VDU1ubiquitin specific protease 33; VHL-interacting deubiquitinating enzyme 1
Molecular Weight
Mass (kDA):
106.727 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p31.1 |
| Sequence: | 1; NC_000001.11 (77695987..77759852, complement) |
Tissue Specificity
Widely expressed.
Subcellular Localizations
Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Associates with centrosomes predominantly in S and G2 phases but less in G1 phase (PubMed:23486064).; [Isoform 3]: Golgi apparatus.
Diseases
- Malignant Neoplasms
- Von Hippel-lindau Syndrome
- Neoplasms
- Malignant Neoplasm Of Prostate
- Lung Injury
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Respiratory Distress Syndrome, Adult
- Respiratory Distress
- Fibrosis
- Mammary Neoplasms
Interacting Proteins
- SELENBP1
Pathways
- Localization
- Secretory Pathway
- Golgi Localization
- Cell Migration
- Signal Transmission
- Brain Development
- Endocytosis
- Conjugation
- Response To Oxidative Stress
- Coagulation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/USP33
bosterbio.com/bosterbio-gene-info-cards/USP33
References
PMID: 11739384 by Li Z., et al. Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein.
PMID: 12865408 by Curcio-Morelli C., et al. Deubiquitination of type 2 iodothyronine deiodinase by von Hippel- Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation.