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PHLPP2 Antibodies
AND PHLPP2 ELISA kits, PHLPP2 Proteins
Many biological assays use antibodies to detect PHLPP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PHLPP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PHLPP2 antibodies...
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PHLPP2 Infographic by Boster Bio
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PHLPP2 Overview
Facts about PH domain leucine-rich repeat-containing protein phosphatase 2.
PH domain leucine-rich repeat-containing protein phosphatase 2 (PHLPP2)
Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of all members of the AGC Ser/Thr protein kinase family; especially acts on'Ser-473' of AKT1,'Ser-660' of PRKCB isoform beta-II and'Ser-657' of PRKCA.
Akt modulates the balance between cell survival and apoptosis by means of a cascade that primarily alters the function of transcription factors that govern pro- and antiapoptotic genes. Dephosphorylation of'Ser- 473' of Akt triggers apoptosis and reduces cell proliferation.
Gene Information
| Human | |
|---|---|
| Gene Name: | PHLPP2 |
| Uniprot: | Q6ZVD8 |
| Entrez: | 23035 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
EC 3.1.3.16; KIAA0931PH domain leucine-rich repeat-containing protein phosphatase 2; PH domain and leucine rich repeat protein phosphatase 2; PH domain and leucine rich repeat protein phosphatase-like; PH domain leucine-rich repeat-containing protein phosphatase-like; PHLPPLPHLPP-like
Molecular Weight
Mass (kDA):
146.751 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16q22.2 |
| Sequence: | 16; NC_000016.10 (71644924..71724701, complement) |
Tissue Specificity
In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or significantly decreased in 80% of tested tumors (at protein level).
Subcellular Localizations
Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. In colorectal cancer tissue, expression is concentrated in the cytoplasm and nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Malignant Tumor Of Colon
- Lymphoma
- Cell Transformation, Neoplastic
- Mammary Neoplasms
- Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse
- Glioblastoma
- Diabetes Mellitus
- Leukemia
- Neoplasm Metastasis
Interacting Proteins
- SLC9A3R1
Pathways
- Cell Proliferation
- Translation
- Cell Death
- Cell Growth
- Localization
- Transport
PTMs
- Phosphorylation
Research Areas
- Cancer
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PHLPP2
bosterbio.com/bosterbio-gene-info-cards/PHLPP2
References
PMID: 17386267 by Brognard J., et al. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.
PMID: 18162466 by Gao T., et al. The phosphatase PHLPP controls the cellular levels of protein kinase C.