USP22 Antibodies

AND USP22 ELISA kits, USP22 Proteins

Many biological assays use antibodies to detect USP22, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with USP22 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop USP22 antibodies...

We validate the specificity of these antibodies to USP22 by testing them on tissues known to express USP22 positively and negatively. Browse below to find the USP22 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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USP22 Infographic by Boster Bio

All USP22 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-USP22 Monoclonal Antibody

4 Q&As

Human

Flow Cytometry, IP, IF, ICC, WB

$370
Cat # M03887
100 μl

Anti-USP22 Antibody

Human

Flow Cytometry, IP, IF, ICC, WB

$405
Cat # A03887
100ul

Anti-USP22 Rabbit Monoclonal Antibody

Human, Mouse, Rat

IP, IF, ICC, WB

$370
Cat # M03887-1
100 μl/vial

Anti-USP22 Antibody Picoband®

Human, Mouse, Rat

$370
Cat # A03887-2
100 μg/vial

USP22 (NM_015276) Human Over-expression Lysate

Human

$960
Cat # LS023326
100 µg

USP22 Overview

Facts about Ubiquitin carboxyl-terminal hydrolase 22.

USP22 3D structure. Source: alphafold

Ubiquitin carboxyl-terminal hydrolase 22 (USP22)

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator.

Recruited to specific gene promoters by activators such as MYC, where it's required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.

Gene Information

Human
Gene Name:	USP22
Uniprot:	Q9UPT9
Entrez:	23326

Family

Belongs to:

peptidase C19 family

Alternative Names

Deubiquitinating enzyme 22; EC 3.1.2.15; EC 3.4.19.12; KIAA1063ubiquitin carboxyl-terminal hydrolase 22; KIAA1064; ubiquitin specific peptidase 22; ubiquitin specific peptidase 3-like; ubiquitin specific protease 22; Ubiquitin Thioesterase 22; Ubiquitin thiolesterase 22; ubiquitin-specific processing protease 22; Ubiquitin-specific-processing protease 22; USP22; USP3L

Molecular Weight

Mass (kDA):
59.961 kDA

Genomic Context


Human

Location:	17p11.2
Sequence:	17; NC_000017.11 (20999596..21043409, complement)

Tissue Specificity

Moderately expressed in various tissues including heart and skeletal muscle, and weakly expressed in lung and liver.

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Neoplasm Metastasis
Colorectal Cancer
Cell Transformation, Neoplastic
Colorectal Neoplasms
Metastatic Malignant Neoplasm To The Lymph Node
Malignant Squamous Cell Neoplasm
Lung Neoplasms
Non-small Cell Lung Carcinoma
Liver Carcinoma

Lymphatic Metastasis
Leukemia
Stomach Neoplasms
Adenoma
Metastatic Malignant Neoplasm To The Liver
Malignant Neoplasm Of Breast

Interacting Proteins

AASDHPPT
FUBP1
NFATC2

Pathways

Cell Cycle
Cell Proliferation
Rna Interference
Oncogenesis
G1 Phase
Cell Cycle Arrest
Cell Growth
Dna Repair
Immune Response
Virulence
Localization

Cell Division
Asymmetric Cell Division
Histone Acetylation
Telomere Maintenance
Chromatin Silencing
Autophagy

PTMs

Ubiquitination
Phosphorylation

Acetylation
Deacetylation

Research Areas

Cancer
Cell Cycle and Replication
Signal Transduction
Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/USP22

References

PMID: 16378762 by Lee H.-J., et al. The expression patterns of deubiquitinating enzymes, USP22 and Usp22.

PMID: 18206972 by Zhao Y., et al. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.