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- Table of Contents
Facts about Ubiquitin carboxyl-terminal hydrolase 13.
Additionally deubiquitinates USP10, an essential regulator of p53/TP53 stability. Subsequently, PIK3C3/VPS34- containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels through USP10 and USP13.
Human | |
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Gene Name: | USP13 |
Uniprot: | Q92995 |
Entrez: | 8975 |
Belongs to: |
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peptidase C19 family |
Deubiquitinating enzyme 13; EC 3.1.2.15; EC 3.4.19.12; Isopeptidase T-3; IsoT-3; ISOT3IsoT-3; ubiquitin carboxyl-terminal hydrolase 13; ubiquitin specific peptidase 13 (isopeptidase T-3); ubiquitin specific protease 13 (isopeptidase T-3); Ubiquitin Thioesterase 13; Ubiquitin thiolesterase 13; Ubiquitin-specific-processing protease 13; USP13
Mass (kDA):
97.327 kDA
Human | |
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Location: | 3q26.33 |
Sequence: | 3; NC_000003.12 (179653040..179789401) |
Highly expressed in ovary and testes.
PMID: 9841226 by Timms K.M., et al. The genomic organization of Isopeptidase T-3 (ISOT-3), a new member of the ubiquitin specific protease family (UBP).
PMID: 17653289 by Catic A., et al. Screen for ISG15-crossreactive deubiquitinases.