This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Netrin receptor UNC5C.
Axon repulsion in growth cones may result from its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC.
Human | |
---|---|
Gene Name: | UNC5C |
Uniprot: | O95185 |
Entrez: | 8633 |
Belongs to: |
---|
unc-5 family |
netrin receptor UNC5C; Protein unc-5 homolog 3; Protein unc-5 homolog C; unc-5 homolog 3; unc-5 homolog C (C. elegans); UNC5C; UNC5H3; UNC5H3unc5 (C.elegans homolog) c
Mass (kDA):
103.146 kDA
Human | |
---|---|
Location: | 4q22.3 |
Sequence: | 4; NC_000004.12 (95162504..95549210, complement) |
Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or adult lung.
Cell membrane; Single-pass type I membrane protein. Cell surface. Cell junction, synapse, synaptosome. Cell projection, axon. Cell projection, dendrite. Cell projection, growth cone. Cell projection, lamellipodium. Cell projection, filopodium.
PMID: 9782087 by Ackerman S.L., et al. Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23.
PMID: 12655055 by Thiebault K., et al. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment.