Ribonuclease T2 Antibodies

AND RNASET2 ELISA kits, Ribonuclease T2 Proteins

Many biological assays use antibodies to detect Ribonuclease T2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ribonuclease T2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ribonuclease T2 antibodies...

We validate the specificity of these antibodies to Ribonuclease T2 by testing them on tissues known to express RNASET2 positively and negatively. Browse below to find the RNASET2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RNASET2 Infographic by Boster Bio

All RNASET2 Products

Product

Figures

Specificity

Applications

Price

Anti-Ribonuclease T2 RNASET2 Antibody

Human, Mouse, Rat

ELISA, IF, ICC, WB

$449
Cat # A05281
0.1 mg

Ribonuclease T2 (RNASET2) (NM_003730) Human Over-expression Lysate

Human

$628
Cat # LS008635
100 µg

RNASET2 Overview

Facts about Ribonuclease T2.

RNASET2 3D structure. Source: alphafold

Ribonuclease T2 (RNASET2)

Has ribonuclease activity, with greater activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity).

Probably plays a role in cellular RNA catabolism. .

Gene Information

Human
Gene Name:	RNASET2
Uniprot:	O00584
Entrez:	8635

Family

Belongs to:

RNase T2 family

Alternative Names

EC 3.1.27.-; EC 3.1.27.1; FLJ10907; FLJ42372; Ribonuclease 6; ribonuclease T2; RNASE6PLbA514O12.3

Molecular Weight

Mass (kDA):
29.481 kDA

Genomic Context


Human

Location:	6q27
Sequence:	6; NC_000006.12 (166922113..166956580, complement)

Tissue Specificity

Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain.

Subcellular Localizations

Secreted. Lysosome lumen. Endoplasmic reticulum lumen. Subcellular fractionation of transfected ovarian cancer cells reveals full-length RNASET2 in the endoplasmic reticulum fraction and the 2 smaller RNASET2 proteolytic products in the lysosome fraction.

Diseases

Neoplasms
Malignant Neoplasms
Ovarian Neoplasm
Malignant Neoplasm Of Ovary
Melanoma
Carcinoma
Cell Transformation, Neoplastic
Leukoencephalopathies
Epithelial Ovarian Cancer
Hematologic Neoplasms
Neoplasm Metastasis
Congenital Cytomegalovirus Infection

Tumor Progression
Leukemia, T-cell
Stomatitis
Mitochondrial Damage
Neoplasm Invasiveness
Parasitic Diseases
Tumor Angiogenesis

Pathways

Senescence
Cell Proliferation
Localization
Secretory Pathway
Response To Stress
Fertilization
Brain Development
Tube Formation
Glycosylation
Myelination
Sperm Motility
Cell Cycle
Cell Death

Cell Motility
Cell Differentiation
Cell Growth
Angiogenesis
Cellular Response To Stress
Pathogenesis
Secretion

PTMs

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RNASET2

References

PMID: 9192857 by Trubia M., et al. Mammalian Rh/T2/S-glycoprotein ribonuclease family genes: cloning of a human member located in a region of chromosome 6 (6q27) frequently deleted in human malignancies.

PMID: 11821951 by Liu Y., et al. Physical and transcript map of the region between D6S264 and D6S149 on chromosome 6q27, the minimal region of allele loss in sporadic epithelial ovarian cancer.