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- Table of Contents
Facts about Ribonuclease T2.
Probably plays a role in cellular RNA catabolism. .
Human | |
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Gene Name: | RNASET2 |
Uniprot: | O00584 |
Entrez: | 8635 |
Belongs to: |
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RNase T2 family |
EC 3.1.27.-; EC 3.1.27.1; FLJ10907; FLJ42372; Ribonuclease 6; ribonuclease T2; RNASE6PLbA514O12.3
Mass (kDA):
29.481 kDA
Human | |
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Location: | 6q27 |
Sequence: | 6; NC_000006.12 (166922113..166956580, complement) |
Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain.
Secreted. Lysosome lumen. Endoplasmic reticulum lumen. Subcellular fractionation of transfected ovarian cancer cells reveals full-length RNASET2 in the endoplasmic reticulum fraction and the 2 smaller RNASET2 proteolytic products in the lysosome fraction.
PMID: 9192857 by Trubia M., et al. Mammalian Rh/T2/S-glycoprotein ribonuclease family genes: cloning of a human member located in a region of chromosome 6 (6q27) frequently deleted in human malignancies.
PMID: 11821951 by Liu Y., et al. Physical and transcript map of the region between D6S264 and D6S149 on chromosome 6q27, the minimal region of allele loss in sporadic epithelial ovarian cancer.