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Netrin receptor UNC5A Antibodies
AND Unc5a ELISA kits, Netrin receptor UNC5A Proteins
Many biological assays use antibodies to detect Netrin receptor UNC5A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Netrin receptor UNC5A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Netrin receptor UNC5A antibodies...
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Unc5a Overview
Facts about Netrin receptor UNC5A.
Netrin receptor UNC5A (Unc5a)
Receptor for netrin required for axon guidance (PubMed:9126742, PubMed:10399920). Functions at the netrin signaling pathway and promotes neurite outgrowth in response to NTN1 (PubMed:19755150).
Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin (PubMed:10399920). Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion (PubMed:10399920).
Gene Information
| Rat | |
|---|---|
| Gene Name: | Unc5a |
| Uniprot: | O08721 |
| Entrez: | 60629 |
Family
| Belongs to: |
|---|
| unc-5 family |
Alternative Names
KIAA1976netrin receptor UNC5A; netrin receptor Unc5h1; Protein unc-5 homolog 1; Protein unc-5 homolog A; unc5 (C.elegans homolog) a; unc-5 homolog 1; unc-5 homolog A (C. elegans); UNC5A; UNC5H1; UNC5H1FLJ16449
Molecular Weight
Mass (kDA):
98.841 kDA
Genomic Context
| Rat | |
|---|---|
| Location: | 17p14 |
| Sequence: | 17; |
Tissue Specificity
Mainly expressed in regions of differentiating neurons. Expressed at early stages of neural tube development in the ventral spinal cord. In developing hindbrain, it colocalizes with a number of cranial motor neuron subpopulations from embryonic E11 to E14, while DCC is expressed by motor neurons at E12. Also expressed in non-neural structures, such as the basal plane of the hindbrain and midbrain, in the developing hypothalamus, thalamus and in the pallidum.
Diseases
- Malignant Neoplasms
- Colorectal Cancer
- Nervousness
- Malignant Tumor Of Colon
- Neoplasms
- Pathologic Neovascularization
- Cell Invasion
- Neuroblastoma
- Malignant Paraganglionic Neoplasm
- Tissue Adhesions
- Epilepsy
- Inflammation
- Reperfusion Injury
Pathways
- Cell Migration
- Axon Guidance
- Cell Death
- Cell Adhesion
- Cell Proliferation
- Chemokine Production
- Regulation Of Cell Adhesion
- Tissue Morphogenesis
- Dna Methylation
- Cell-matrix Adhesion
- Endocytosis
- Neuron Development
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Unc5a
bosterbio.com/bosterbio-gene-info-cards/Unc5a
References
PMID: 9126742 by Leonardo E.D., et al. Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors.
PMID: 10399920 by Hong K., et al. A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion.