Protein unc-13 homolog D Antibodies

AND Unc13d ELISA kits, Protein unc-13 homolog D Proteins

Many biological assays use antibodies to detect Protein unc-13 homolog D, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein unc-13 homolog D in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein unc-13 homolog D antibodies...

We validate the specificity of these antibodies to Protein unc-13 homolog D by testing them on tissues known to express Unc13d positively and negatively. Browse below to find the Unc13d antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Unc13d Infographic by Boster Bio

All Unc13d Products

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Product

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Specificity

Applications

Price

Anti-Protein unc-13 homolog D UNC13D Antibody

Human, Mouse

$405
Cat # A03088
100ul

Munc 13 4 (UNC13D) (NM_199242) Human Recombinant Protein

$813
Cat # PROTQ70J99
20 µg

Anti-Munc 13 4 (UNC13D) Mouse Monoclonal Antibody [Clone ID: OTI1F4]

Human, Mouse, Rat

$523
Cat # M03088
100 µl

Munc 13 4 (UNC13D) (NM_199242) Human Over-expression Lysate

Human

$628
Cat # LS201294
100 µg

Unc13d Overview

Facts about Protein unc-13 homolog D.

Protein unc-13 homolog D (Unc13d)

Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming in the immunologic synapse.

Regulates assembly of recycling and late endosomal structures, causing the formation of an endosomal exocytic compartment which fuses with perforin-containing granules in the immunologic synapse and licences them for exocytosis (By similarity). Regulates Ca(2+)- dependent secretory lysosome exocytosis in mast cells.

Gene Information

Mouse
Gene Name:	Unc13d
Uniprot:	B2RUP2
Entrez:	70450

Family

Belongs to:

unc-13 family

Alternative Names

FHL3; HLH3; HPLH3; Munc13-4; Munc13-4protein unc-13 homolog D; unc-13 homolog D (C. elegans); UNC13D

Molecular Weight

Mass (kDA):
123.119 kDA

Genomic Context


Mouse

Location:	11\|11 E2
Sequence:	11;

Tissue Specificity

Mast cells.

Diseases

Lymphohistiocytosis, Hemophagocytic
Familial Hemophagocytic Lymphocytosis
Nervousness
Immunologic Deficiency Syndromes
Chediak-higashi Syndrome
Virus Diseases
Epstein-barr Virus Infections
Infective Disorder
Anemia
Hypopigmentation-immunodeficiency Disease
Immune System Diseases

Histiocytosis Haematophagic
Griscelli Syndrome, Type 2
Inflammation
Hemophagocytic Lymphohistiocytosis, Familial, 5
Arthritis, Juvenile Rheumatoid
Macrophage Activation Syndrome

Pathways

Exocytosis
Secretion
Macrophage Activation
Localization
Immune Response
Secretory Pathway
Membrane Fusion
Cytokine Production
Transport
Cell Activation
Vesicle Transport
Lymphocyte Homeostasis
Pathogenesis

Gene Silencing
Pigmentation
Platelet Activation
Tropism
Cytoskeleton Organization
Sensitization
Mrna Splicing

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Unc13d

References

PMID: 17420270 by Crozat K., et al. Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis.

PMID: 18354201 by Higashio H., et al. Doc2 alpha and Munc13-4 regulate Ca(2+) -dependent secretory lysosome exocytosis in mast cells.