ULK2 Antibodies

AND ULK2 ELISA kits, ULK2 Proteins

Many biological assays use antibodies to detect ULK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ULK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ULK2 antibodies...

We validate the specificity of these antibodies to ULK2 by testing them on tissues known to express ULK2 positively and negatively. Browse below to find the ULK2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ULK2 Infographic by Boster Bio

All ULK2 Products

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Specificity

Applications

Price

Anti-ULK2 Antibody

7 Q&As

Human, Mouse, Rat

ELISA, WB

$399
Cat # A05219
100μl

Anti-ULK2 Antibody

Human

ELISA, IF, IHC-P, WB

$449
Cat # A05219-1
0.1 mg

ULK2 (NM_014683) Human Over-expression Lysate

Human

$628
Cat # LS009706
100 µg

ULK2 Overview

Facts about Serine/threonine-protein kinase ULK2.

ULK2 3D structure. Source: alphafold

Serine/threonine-protein kinase ULK2 (ULK2)

Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to modulate the formation of autophagophores, the precursors of autophagosomes. Section of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) through interaction with RPTOR.

Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however these information need additional evidences.

Gene Information

Human
Gene Name:	ULK2
Uniprot:	Q8IYT8
Entrez:	9706

Family

Belongs to:

protein kinase superfamily

Alternative Names

ATG1B; EC 2.7.11; EC 2.7.11.1; KIAA0623serine/threonine-protein kinase ULK2; unc-51 (C. elegans)-like kinase 2; Unc51.2; unc-51-like kinase 2 (C. elegans); Unc-51-like kinase 2

Molecular Weight

Mass (kDA):
112.694 kDA

Genomic Context


Human

Location:	17p11.2
Sequence:	17; NC_000017.11 (19770828..19867936, complement)

Subcellular Localizations

Cytoplasmic vesicle membrane; Peripheral membrane protein. Localizes to pre-autophagosomal membrane.

Diseases

Neoplasms
Tissue Adhesions
Sclerosis
Malignant Squamous Cell Neoplasm
Malignant Neoplasms
Nervousness
Malignant Neoplasm Of Breast
Mammary Neoplasms
Senile Plaques

Tuberous Sclerosis
Neurofibrillary Tangles
Carcinoma

Pathways

Autophagy
Cell Death
Response To Nutrient
Regulation Of Autophagy
Localization
Cell Growth
Transport
Vesicle Transport
Cell Proliferation
Programmed Cell Death
Regulation Of Axon Extension

Endocytosis
Response To Starvation
Axon Extension
Macroautophagy
Cell Cycle
Catabolic Process

PTMs

Phosphorylation

Dephosphorylation

Research Areas

Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ULK2

References

PMID: 18936157 by Chan E.Y.W., et al. Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism.

PMID: 21460635 by Lee E.J., et al. The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy.