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- Table of Contents
2 Citations 7 Q&As
Facts about E3 ubiquitin-protein ligase UHRF2.
Ubiquitinates cyclins, CCND1 and CCNE1, in a seemingly phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP resulting in its degradation by the proteasome.
Mouse | |
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Gene Name: | Uhrf2 |
Uniprot: | Q7TMI3 |
Entrez: | 109113 |
Belongs to: |
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No superfamily |
DKFZp434B0920; DKFZp686G0837; E3 ubiquitin-protein ligase UHRF2; EC 6.3.2; EC 6.3.2.-; MGC33463; NIRFUbiquitin-like-containing PHD and RING finger domains protein 2; Np95/ICBP90-like RING finger protein; Np95-like RING finger protein; Nuclear protein 97; Nuclear zinc finger protein Np97; RNF107RING finger protein 107; Ubiquitin-like PHD and RING finger domain-containing protein 2; ubiquitin-like with PHD and ring finger domains 2; ubiquitin-like, containing PHD and RING finger domains, 2; URF2
Mass (kDA):
90.106 kDA
Mouse | |
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Location: | 19|19 C1 |
Sequence: | 19; |
PMID: 21598301 by Pichler G., et al. Cooperative DNA and histone binding by Uhrf2 links the two major repressive epigenetic pathways.
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