NEDD8-conjugating enzyme UBE2F (Ube2f)

Accepts the ubiquitin-like protein NEDD8 from the UBA3- NAE1 E1 complicated and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complicated neddylates specific target proteins, such as CUL5.

.