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- Table of Contents
Facts about Ubiquitin-like modifier-activating enzyme 6.
Differs from UBE1 in its specificity for substrate E2 charging. Doesn't bill cell cycle E2s, such as CDC34.
Human | |
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Gene Name: | UBA6 |
Uniprot: | A0AVT1 |
Entrez: | 55236 |
Belongs to: |
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ubiquitin-activating E1 family |
E1-L2; FLJ10808; FLJ23367; Monocyte protein 4; MOP4; MOP-4; UBA6, ubiquitin-activating enzyme E1; UBE1L2; Ubiquitin-activating enzyme 6; ubiquitin-activating enzyme E1-like 2; Ubiquitin-activating enzyme E1-like protein 2; ubiquitin-like modifier activating enzyme 6; ubiquitin-like modifier-activating enzyme 6
Mass (kDA):
117.97 kDA
Human | |
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Location: | 4q13.2 |
Sequence: | 4; NC_000004.12 (67612652..67701155, complement) |
Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis.
PMID: 15202508 by Zhu H., et al. Identification and characteristics of a novel E1 like gene nUBE1L in human testis.
PMID: 17597759 by Jin J., et al. Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging.