Tribbles homolog 3 (TRIB3)

May bind directly to and hide the'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity.

Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases.