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- Table of Contents
Facts about Tumor protein p53-inducible nuclear protein 2.
May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them into the autophagosome membrane by interacting with VMP1 where, in collaboration with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.
Human | |
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Gene Name: | TP53INP2 |
Uniprot: | Q8IXH6 |
Entrez: | 58476 |
Belongs to: |
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No superfamily |
C20orf110; chromosome 20 open reading frame 110; diabetes and obesity regulated; dJ1181N3.1; DKFZp434B2411; DKFZp434O0827; DOR; FLJ21759; FLJ23500; p53-inducible protein U; PINHPIG-U; tumor protein p53 inducible nuclear protein 2; tumor protein p53-inducible nuclear protein 2
Mass (kDA):
23.98 kDA
Human | |
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Location: | 20q11.22 |
Sequence: | 20; NC_000020.11 (34704344..34713439) |
Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.
PMID: 18030323 by Baumgartner B.G., et al. Identification of a novel modulator of thyroid hormone receptor- mediated action.
PMID: 19145107 by Nowak J., et al. TP53INP2 is the new guest at the table of self-eating.