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- Table of Contents
1 Citations 11 Q&As
Facts about Tumor necrosis factor receptor superfamily member 17.
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL.
Promotes B-cell survival and plays a role in the regulation of humoral immunity.Activates NF-kappa-B and JNK. .
Human | |
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Gene Name: | TNFRSF17 |
Uniprot: | Q02223 |
Entrez: | 608 |
Belongs to: |
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No superfamily |
B cell maturation antigen; B-cell maturation protein; BCMA; BCMAtumor necrosis factor receptor superfamily member 17; BCMB-cell maturation factor; CD269 antigen; CD269; TNFRSF13A; TNFRSF17; tumor necrosis factor receptor superfamily, member 17
Mass (kDA):
20.165 kDA
Human | |
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Location: | 16p13.13 |
Sequence: | 16; NC_000016.10 (11965210..11968068) |
Expressed in mature B-cells, but not in T- cells or monocytes.
Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Perinuclear Golgi-like structures.
PMID: 1396583 by Laabi Y., et al. A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma.
PMID: 8165126 by Laabi Y., et al. The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed.
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