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- Table of Contents
Facts about Tumor necrosis factor alpha-induced protein 8-like protein 2.
Prevents hyperresponsiveness of the immune system and keeps immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation.
Mouse | |
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Gene Name: | Tnfaip8l2 |
Uniprot: | Q9D8Y7 |
Entrez: | 69769 |
Belongs to: |
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TNFAIP8 family |
FLJ23467; Inflammation factor protein 20; TIPE2; TIPE2inflammation factor 20; TNF alpha-induced protein 8-like protein 2; TNFAIP8-like protein 2; tumor necrosis factor alpha-induced protein 8-like protein 2; tumor necrosis factor, alpha-induced protein 8-like 2; tumor necrosis factor, alpha-induced protein 8-like protein 2
Mass (kDA):
20.615 kDA
Mouse | |
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Location: | 3|3 F2.1 |
Sequence: | 3; |
Expressed in thymus, spleen, lymph node and small intestine, but not in liver, heart, muscle, testis, spinal cord or brain. Up-regulated in the spinal cord of mice with experimental autoimmune encephalomyelitis. Constitutively expressed by macrophages, B and T-lymphocytes at various developmental stages.
PMID: 18455983 by Sun H., et al. TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis.
*More publications can be found for each product on its corresponding product page