Toll-like receptor 6 Antibodies

AND TLR6 ELISA kits, Toll-like receptor 6 Proteins

Many biological assays use antibodies to detect Toll-like receptor 6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Toll-like receptor 6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Toll-like receptor 6 antibodies...

We validate the specificity of these antibodies to Toll-like receptor 6 by testing them on tissues known to express TLR6 positively and negatively. Browse below to find the TLR6 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TLR6 Infographic by Boster Bio

All TLR6 Products

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Specificity

Applications

Price

Anti-Toll-like receptor 6 TLR6 Antibody

Human, Mouse

ELISA, ICC, WB

$449
Cat # A01914
0.1 mg

Anti-Tlr6 Antibody Picoband®

Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A01914-2
100 μg/vial

TLR6 (NM_006068) Human Over-expression Lysate

Human

$960
Cat # LS010333
100 µg

TLR6 Overview

Facts about Toll-like receptor 6.

TLR6 3D structure. Source: alphafold

Toll-like receptor 6 (TLR6)

Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides (PubMed:20037584). In response to diacylated lipopeptides, forms the activation bunch TLR2:TLR6:CD14:CD36, this bunch triggers signaling from the cell surface and then is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211).

Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.

Gene Information

Human
Gene Name:	TLR6
Uniprot:	Q9Y2C9
Entrez:	10333

Family

Belongs to:

Toll-like receptor family

Alternative Names

CD286 antigen; CD286; TLR6; toll-like receptor 6

Molecular Weight

Mass (kDA):
91.88 kDA

Genomic Context


Human

Location:	4p14
Sequence:	4; NC_000004.12 (38823680..38857767, complement)

Tissue Specificity

Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft. Golgi apparatus. Upon complex formation with CD36 and TLR4, internalized through dynamin-dependent endocytosis. Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus (PubMed:16880211).