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Protein MRVI1 Antibodies
AND MRVI1 ELISA kits, Protein MRVI1 Proteins
Many biological assays use antibodies to detect Protein MRVI1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein MRVI1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein MRVI1 antibodies...
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MRVI1 Overview
Facts about Protein MRVI1.
Protein MRVI1 (MRVI1)
Plays a role as NO/PRKG1-dependent regulator of IP3- induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 at a macrocomplex.
Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle leading to NO-dependent relaxation.
Gene Information
| Human | |
|---|---|
| Gene Name: | MRVI1 |
| Uniprot: | Q9Y6F6 |
| Entrez: | 10335 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
murine retrovirus integration site 1 homolog
Molecular Weight
Mass (kDA):
97.957 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p15.4 |
| Sequence: | 11; NC_000011.10 (10573091..10693988, complement) |
Tissue Specificity
Expressed in the colon, rectum, and cultured colonic smooth muscle. Detected in various cancer cell lines.
Subcellular Localizations
Cytoplasm, perinuclear region. Sarcoplasmic reticulum. Membrane; Single-pass membrane protein.
Diseases
- Observation Of Neuromuscular Block
- Malignant Neoplasms
- Atherosclerosis
- Leukemia
- Thrombus
- Infarction
- Blood Platelet Disorders
- Carcinoma
- Myocardial Infarction
- Cardiovascular Diseases
- Arterial Thrombosis
- Hemorrhage
- Neoplasms
Pathways
- Localization
- Platelet Aggregation
- Platelet Activation
- Cell Growth
- Secretion
- Relaxation Of Smooth Muscle
- Cell Migration
- Smooth Muscle Contraction
- Immune Response
- Muscle Contraction
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MRVI1
bosterbio.com/bosterbio-gene-info-cards/MRVI1
References
PMID: 10321731 by Shaughnessy J.D. Jr., et al. Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1.
PMID: 14729908 by Fritsch R.M., et al. InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle.