Tchp Antibodies

AND Tchp ELISA kits, Tchp Proteins

Many biological assays use antibodies to detect Tchp, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tchp in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tchp antibodies...

We validate the specificity of these antibodies to Tchp by testing them on tissues known to express Tchp positively and negatively. Browse below to find the Tchp antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Tchp Infographic by Boster Bio

All Tchp Products

Product

Figures

Specificity

Applications

Price

Anti-TCHP Antibody

Human

ELISA, WB

$380
Cat # A11231
100ul

TCHP (NM_032300) Human Over-expression Lysate

Human

$628
Cat # LS084260
100 µg

Tchp Overview

Facts about Trichoplein keratin filament-binding protein.

Trichoplein keratin filament-binding protein (Tchp)

Tumor suppressor which has the capacity to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery.

May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral areas of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity).

Gene Information

Mouse
Gene Name:	Tchp
Uniprot:	Q3TVW5
Entrez:	77832

Family

Belongs to:

TCHP family

Alternative Names

TpMs; trichoplein, keratin filament binding

Molecular Weight

Mass (kDA):
60.642 kDA

Genomic Context


Mouse

Location:	5\|5 F
Sequence:	5;

Tissue Specificity

Expressed in all tissues examined, including brain, liver, small intestine, large intestine, lung and heart. Found concentrated in tubular structures within hepatocytes, and in the apical cortical region and desmosomes of the apical junctional domain in enterocytes of the small intestine. In the hair follicle, localized at the outer root sheath. Also expressed in blood vessels (at protein level).

Diseases

Malignant Squamous Cell Neoplasm
Laryngeal Neoplasm
Angina Pectoris
Neoplasm Metastasis
Coronary Heart Disease
Metastatic Malignant Neoplasm To The Lymph Node
Infarction
Malignant Neoplasm Of Larynx
Neonatal Hypocalcemia
Carcinoma
Digeorge Syndrome
Myocardial Infarction
Congenital Heart Defects

Malignant Neoplasms
Pain
Chronic Stable Angina
Cell Invasion
Mucinous Adenocarcinoma
Hypocalcemia
Hypoparathyroidism

Pathways

Transport
Microtubule Anchoring
Proton Transport
G1 Phase
Localization
Conjugation

PTMs

Nitration

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Tchp

References

PMID: 15731013 by Nishizawa M., et al. Identification of trichoplein, a novel keratin filament-binding protein.