TUT1 Antibodies

AND TUT1 ELISA kits, TUT1 Proteins

Many biological assays use antibodies to detect TUT1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TUT1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TUT1 antibodies...

We validate the specificity of these antibodies to TUT1 by testing them on tissues known to express TUT1 positively and negatively. Browse below to find the TUT1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TUT1 Infographic by Boster Bio

All TUT1 Products

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Product

Figures

Specificity

Applications

Price

Anti-TUT1/Tutase Antibody

5 Q&As

Human, Mouse

IHC, WB

$360
Cat # A09330
100 µl

TUT1 (NM_022830) Human Over-expression Lysate

Human

$628
Cat # LS064852
100 µg

TUT1 Overview

Facts about Speckle targeted PIP5K1A-regulated poly(A) polymerase.

TUT1 3D structure. Source: alphafold

Speckle targeted PIP5K1A-regulated poly(A) polymerase (TUT1)

Poly(A) polymerase that creates the 3'-poly(A) tail of particular pre-mRNAs. In addition to polyadenylation, it's also necessary for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs.

In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase.

Gene Information

Human
Gene Name:	TUT1
Uniprot:	Q9H6E5
Entrez:	64852

Family

Belongs to:

DNA polymerase type-B-like family

Alternative Names

EC 2.7.7.19; EC 2.7.7.52; FLJ21850; FLJ22267; FLJ22347; MGC131987; MGC149809; nuclear speckle targeted phosphatidylinositol 4-phosphate 5-kinase type I-alpharegulated-poly(A) polymerase; nuclear speckle-targeted PIPK1A-regulated-poly(A) polymerase; PAP-associated domain-containing 2; PAPD2; poly(A) polymerase associated domain containing 2; RBM21; RNA binding motif protein 21; RNA uridylyltransferase; RNA-binding motif protein 21; RNA-binding protein 21; speckle targeted PIP5K1A-regulated poly(A) polymerase; STARPAP; star-PAP; terminal uridylyl transferase 1, U6 snRNA-specific; TUTase; U6 snRN

Molecular Weight

Mass (kDA):
93.847 kDA

Genomic Context


Human

Location:	11q12.3
Sequence:	11; NC_000011.10 (62575052..62591523, complement)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Nucleus, nucleolus. Nucleus speckle.

Interacting Proteins

PIP5K1A

Pathways

Dna Replication
Cell Differentiation
Rna Interference

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TUT1

References

PMID: 16790842 by Trippe R., et al. Identification, cloning, and functional analysis of the human U6 snRNA-specific terminal uridylyl transferase.

PMID: 18172165 by Mullen T.E., et al. Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'.