TSTD1 Antibodies

AND TSTD1 ELISA kits, TSTD1 Proteins

Many biological assays use antibodies to detect TSTD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TSTD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TSTD1 antibodies...

We validate the specificity of these antibodies to TSTD1 by testing them on tissues known to express TSTD1 positively and negatively. Browse below to find the TSTD1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TSTD1 Infographic by Boster Bio

All TSTD1 Products

Product

Figures

Specificity

Applications

Price

Human TSTD1 Recombinant Protein

SDS-PAGE

$250
Cat # PROTQ8NFU3
Starting from 10ug

TSTD1 Overview

Facts about Thiosulfate:glutathione sulfurtransferase.

TSTD1 3D structure. Source: alphafold

Thiosulfate:glutathione sulfurtransferase (TSTD1)

Thiosulfate:glutathione sulfurtransferase (TST) required to generate S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631). Provides the connection between the first step in mammalian H(2)S metabolism conducted from the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate (PubMed:24981631).

The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor (PubMed:24981631). .

Gene Information

Human
Gene Name:	TSTD1
Uniprot:	Q8NFU3
Entrez:	100131187

Family

Belongs to:

No superfamily

Alternative Names

KAT; putative thiosulfate sulfurtransferase KAT; thiosulfate sulfurtransferase (rhodanese)-like domain containing 1; thiosulfate sulfurtransferase KAT, putative

Molecular Weight

Mass (kDA):
12.53 kDA

Genomic Context


Human

Location:	1q23.3
Sequence:	1; NC_000001.11 (161037631..161038964, complement)

Tissue Specificity

Highly expressed in kidney, liver and skeletal muscle. Lower levels of expression in heart, colon, thymus, spleen, placenta and lung. Weakly expressed in brain, small intestine and peripheral blood leukocytes. Expressed at high levels in the breast carcinoma cell lines MCF-7 and MDA-MB-468 and at a lower level in the breast carcinoma cell line MDA-MB-231, the colon carcinoma call line LoVo and the lung carcinoma cell line A- 549. No expression in the cell lines EFO-27 and HeLa, or the normal breast tissue cell lines MCF-10A and H184A1. Detected in invasive ductal carcinoma, but not in the adjacent tissues.

Subcellular Localizations

Cytoplasm, perinuclear region. Localized around the nuclear membranes.

Diseases

Invasive Ductal Breast Carcinoma
Cell Transformation, Neoplastic
Malignant Neoplasms
Neoplasms
Ductal Carcinoma
Malignant Neoplasm Of Lung
Carcinoma

Ductal Breast Carcinoma

Pathways

Translation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TSTD1

References

PMID: 12817473 by Wenzel K., et al. Identification and characterization of KAT, a novel gene preferentially expressed in several human cancer cell lines.

PMID: 24981631 by Melideo S.L., et al. Biosynthesis of a central intermediate in hydrogen sulfide metabolism by a novel human sulfurtransferase and its yeast ortholog.