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- Table of Contents
Facts about Testis-specific Y-encoded-like protein 5.
Suppresses p53/TP53 protein levels and boosts its own ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7.
Human | |
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Gene Name: | TSPYL5 |
Uniprot: | Q86VY4 |
Entrez: | 85453 |
Belongs to: |
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nucleosome assembly protein (NAP) family |
KIAA1750; testis-specific Y-encoded-like protein 5; TSPY-like 5; TSPY-like protein 5
Mass (kDA):
45.143 kDA
Human | |
---|---|
Location: | 8q22.1 |
Sequence: | 8; NC_000008.11 (97273488..97277928, complement) |
PMID: 20079711 by Kim E.J., et al. TSPYL5 is involved in cell growth and the resistance to radiation in A549 cells via the regulation of p21(WAF1/Cip1) and PTEN/AKT pathway.
PMID: 21170034 by Epping M.T., et al. TSPYL5 suppresses p53 levels and function by physical interaction with USP7.